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杨达候

杨达候 助理教授

职务:

电子邮件:dhyang@xmu.edu.cn

办公地点:厦门大学国家传染病诊断试剂与疫苗工程技术研究中心

主要研究领域:体外诊断,微流控,生物微机电系统

个人简介

杨达候博士主要围绕微流控技术、生物微机电系统等开展交叉学科研究,致力于生物医学检测新技术的开发、应用和转化。成果曾多次发表在该领域高水平期刊如:Lab on a Chip, Biosensors and Bioelectronics, Analytical Chemistry等。目前研究方向主要聚焦:单分子免疫检测技术;新型数字PCR技术;单B细胞抗体筛选平台。2022年入选福建省高层次人才(境外引进C类)。


教育背景

2015.9 - 2019.8 新加坡科技设计大学,工程产品开发,博士

2011.9 - 2015.7 电子科技大学,生物医学工程,学士

工作经历

2022.2-至今 bet体育365官网正规,助理教授

2019.9-2021.12 新加坡-麻省理工学院研究与技术联盟中心,博士后

主讲本科课程:临床检验仪器学、微流控技术及其生物医学应用

代表性成果

发表文章

1. D. Yang and Y. Ai; Microfluidic impedance cytometry device with N-shaped electrodes for lateral position measurement of single cells/particles. Lab on a Chip 2019, 19 (21), 3609-3617. (inside front cover)

2. D. Yang*, Y. Zhou*, Y. Zhou, J. Han and Y. Ai#; Biophysical phenotyping of single cells using a differential multiconstriction microfluidic device with self-aligned 3D electrodes. Biosensors and Bioelectronics 2019, 133, 16-23. ( *co-first author,# Corresponding Author)

3. Y. Zhou*, D. Yang*, Y. Zhou, B. L. Khoo, J. Han# and Y. Ai#; Characterizing deformability and electrical impedance of cancer cells in a microfluidic device. Analytical Chemistry 2018, 90 (1), 912-919. ( *co-first author)

4. D. Yang*, G. Subramanian*, J. Duan, S. Gao, L. Bai, R. Chandramohanadas#, Y. Ai#.; A portable image-based cytometer for rapid malaria detection and quantification. PloS One 2017, 12 (6), e017916. ( *co-first author)

5. D. Yang, M. Tayebi, Y. Huang, H. Y. Yang and Y. Ai; A microfluidic DNA sensor based on three-dimensional (3D) hierarchical MoS(2)/Carbon nanotube nanocomposites. Sensors 2016, 16 (11).

6. M. Tayebi, D. Yang, D. J. Collins# and Y. Ai#; Deterministic sorting of submicron particles and extracellular vesicles using a combined electric and acoustic field. Nano Letters 2021, 21(16), 6835-6842.

7. M. Liang, D. Yang, Y. Zhou, P. Li, J. Zhong and Y. Ai; Single cell stretching in viscoelastic fluids with electronically triggered imaging for cellular mechanical phenotyping. Analytical Chemistry 2021, 93 (10), 4567-4575.

8. J. Zhong, D. Yang, Y. Zhou, M. Liang and Y. Ai.; Multi-frequency single cell electrical impedance measurement for label-free cell viability analysis. Analyst 2021, 146 (6), 1848-1858.

9. X. Lu, J. J. M. Chow, S. H. Koo, B. Jiang, T. Y. Tan, D. Yang, et al.; Sheathless and high-throughput bacterial isolation for molecular diagnosis of bloodstream pneumonia infection with non-Newtonian fluid . Lab on a Chip 2021, 21(11), 2163-2177.

10. Y. Yang, Y. Wu, D. Yang, S. H. Neo, N. D. Kadir, D. Goh, et al., Secretive derived from hypoxia preconditioned mesenchymal stem cells promote cartilage regeneration and mitigate joint inflammation via extracellular vesicles. Bioactive Materials 2023, 27, 98-112.

11. S. S. Thamarath, C. A. Tee, S. H. Neo, D. Yang, R. Othman, L. A. Boyer, et al., Rapid and Live-Cell Detection of Senescence in Mesenchymal Stem Cells by Micro Magnetic Resonance Relaxometry, Stem Cells Transl Med 2023, DOI: 10.1093/stcltm/szad014.

12. N. Tan Kwan Zen*, K. K. Zeming*, K. L. Teo, M. Loberas, J. Lee, C. R. Goh, D. Yang , et al.; Scalable mesenchymal stem cell enrichment from bone marrow aspirate using deterministic lateral displacement (DLD) microfluidic sorting, Lab on a Chip 2023, DOI: 10.1039/d3lc00379e.

主持及参与的科研项目

1.国家自然科学基金青年科学基金项目,基于免疫复合物转移的液滴单分子免疫检测技术研究,82302399, 2024.1–2026.12,在研,主持。

2.厦门市科学技术局,厦门市自然科学基金面上项目,3502Z20227167, 基于微流控平台的一体化快速数字PCR 检测,2022.7-2025.6,在研,主持。

3.中华人民共和国科学技术部,国家重点研发计划, 2022YFC0869900, 新冠变异株及重组株对检测试剂影响评价体系的建立, 2022.10-2023.9, 结题, 参与。

4.新加坡国家研究基金会, 新加坡细胞制造项目, CAMP IRG, SMART Centre, 制造个性化医疗的关键分析, 2019.6-2023.5, 结题, 参与。